Product overview:

MAP3K8 mouse monoclonal antibody,clone LBI2E3

Field of research:

MAPK signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway

Summary:

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Alternative names:

AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

MAP3K8

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 277-461 of human MAP3K8(NP_005195) produced in E.coli.

Clone:

LBI2E3

Conjugation:

Unconjugated

Gene name:

mitogen-activated protein kinase kinase kinase 8

Symbol:

MAP3K8

Pathway:

MAPK signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway

Function:

Druggable Genome, Protein Kinase

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com