Product overview:

KLK3 mouse monoclonal antibody, clone LBI2G8

Field of research:

Pathways in cancer, Prostate cancer

Summary:

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Alternative names:

APS; hK3; KLK2A1; PSA

Species reactivity:

Human

Host:

Mouse

Target:

KLK3

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 25-261 of human KLK3(NP_001639) produced in E.coli.

Clone:

LBI2G8

Conjugation:

Unconjugated

Gene name:

kallikrein related peptidase 3

Symbol:

KLK3

Pathway:

Pathways in cancer, Prostate cancer

Function:

Druggable Genome, Protease, Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com