Product overview:

PD-1 (PDCD1) mouse monoclonal antibody, clone LBI15B5

Field of research:

Cell adhesion molecules (CAMs), T cell receptor signaling pathway

Summary:

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

Alternative names:

CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2

Species reactivity:

Human

Host:

Mouse

Target:

PDCD1

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human PDCD1 (NP_005009) produced in HEK293T cell.

Clone:

LBI15B5

Conjugation:

Unconjugated

Gene name:

programmed cell death 1

Symbol:

PDCD1

Pathway:

Cell adhesion molecules (CAMs), T cell receptor signaling pathway

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

FLOW 1:50

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com