Product overview:

TNFRSF10A mouse monoclonal antibody, clone LBI11B12

Field of research:

Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

Summary:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

Alternative names:

APO2; CD261; DR4; TRAILR-1; TRAILR1

Species reactivity:

Human

Host:

Mouse

Target:

TNFRSF10A

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 263-468 of human TNFRSF10A(NP_003835) produced in E.coli.

Clone:

LBI11B12

Conjugation:

Unconjugated

Gene name:

tumor necrosis factor receptor superfamily member 10a

Symbol:

TNFRSF10A

Pathway:

Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com