Product overview:

LOXL2 mouse monoclonal antibody, clone LBI8B2

Field of research:

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Summary:

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

Alternative names:

LOR2; WS9-14

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

LOXL2

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 152-450 of human LOXL2(NP_002309) produced in E.coli.

Clone:

LBI8B2

Conjugation:

Unconjugated

Gene name:

lysyl oxidase like 2

Symbol:

LOXL2

Pathway:

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Function:

Druggable Genome, Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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