Product overview:

ANPEP mouse monoclonal antibody, clone LBI2E4

Field of research:

Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system

Summary:

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]

Alternative names:

APN; CD13; GP150; LAP1; P150; PEPN

Species reactivity:

Human

Host:

Mouse

Target:

ANPEP

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 668-967 of human ANPEP (NP_001141) produced in E.coli.

Clone:

LBI2E4

Conjugation:

Unconjugated

Gene name:

alanyl aminopeptidase, membrane

Symbol:

ANPEP

Pathway:

Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system

Function:

Druggable Genome, ES Cell Differentiation/IPS, Protease, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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