Product overview:

PDX1 mouse monoclonal antibody, clone LBI4H7

Field of research:

Maturity onset diabetes of the young, Type II diabetes mellitus

Summary:

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]

Alternative names:

GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PDX1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human PDX1(NP_000200) produced in E.coli.

Clone:

LBI4H7

Conjugation:

Unconjugated

Gene name:

pancreatic and duodenal homeobox 1

Symbol:

PDX1

Pathway:

Maturity onset diabetes of the young, Type II diabetes mellitus

Function:

Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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