Product overview:

CD3 mouse monoclonal antibody, clone UCHT1

Field of research:

Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

Summary:

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Alternative names:

IMD18; T3E; TCRE

Species reactivity:

Human

Host:

Mouse

Target:

CD3E

Isotype:

IgG1

Immunogen:

Human infant thymocytes and lymphocytes from a patient with Sézary disease

Clone:

UCHT1

Conjugation:

Unconjugated

Gene name:

CD3e molecule

Symbol:

CD3E

Pathway:

Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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