Product overview:

HAVCR2 mouse monoclonal antibody, clone LBI2E2

Field of research:

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Summary:

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

Alternative names:

CD366; HAVcr-2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3

Species reactivity:

Human

Host:

Mouse

Target:

HAVCR2

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 22-202 of human HAVCR2(NP_116171) produced in E.coli.

Clone:

LBI2E2

Conjugation:

Unconjugated

Gene name:

hepatitis A virus cellular receptor 2

Symbol:

HAVCR2

Pathway:

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Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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