Product overview:

KRT8 mouse monoclonal antibody,clone LBI2F5

Field of research:

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Summary:

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Alternative names:

CARD2; CK-8; CK8; CYK8; K2C8; K8; KO

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

KRT8

Isotype:

IgG2b

Immunogen:

Human recombinant protein fragment corresponding to amino acids 91-381 of human KRT8(NP_002264) produced in E.coli.

Clone:

LBI2F5

Conjugation:

Unconjugated

Gene name:

keratin 8

Symbol:

KRT8

Pathway:

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Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

IHC 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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