Product overview:

MMP2 mouse monoclonal antibody, clone LBI4B11

Field of research:

Bladder cancer, GnRH signaling pathway, Leukocyte transendothelial migration, Pathways in cancer

Summary:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Alternative names:

CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

MMP2

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 228-507 of human MMP2(NP_004521) produced in E.coli.

Clone:

LBI4B11

Conjugation:

Unconjugated

Gene name:

matrix metallopeptidase 2

Symbol:

MMP2

Pathway:

Bladder cancer, GnRH signaling pathway, Leukocyte transendothelial migration, Pathways in cancer

Function:

Druggable Genome, Protease

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com