Product overview:

DUSP10 mouse monoclonal antibody, clone LBI2H1

Field of research:

MAPK signaling pathway

Summary:

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Alternative names:

MKP-5; MKP5

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

DUSP10

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 180-482 of human DUSP10(NP_009138) produced in E.coli.

Clone:

LBI2H1

Conjugation:

Unconjugated

Gene name:

dual specificity phosphatase 10

Symbol:

DUSP10

Pathway:

MAPK signaling pathway

Function:

Druggable Genome, Phosphatase

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com