Product overview:

UBE2D2 mouse monoclonal antibody, clone LBI1H4

Field of research:

Ubiquitin mediated proteolysis

Summary:

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Alternative names:

E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

UBE2D2

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human UBE2D2 (NP_003330) produced in E.coli.

Clone:

LBI1H4

Conjugation:

Unconjugated

Gene name:

ubiquitin conjugating enzyme E2 D2

Symbol:

UBE2D2

Pathway:

Ubiquitin mediated proteolysis

Function:

Request info at info@sobekbio.com

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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