Product overview:

NTRK1 mouse monoclonal antibody, clone LBI5B6

Field of research:

Apoptosis, Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Thyroid cancer

Summary:

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

Alternative names:

MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

NTRK1

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 440-796 of human NTRK1(NP_002520) produced in E.coli.

Clone:

LBI5B6

Conjugation:

Unconjugated

Gene name:

neurotrophic receptor tyrosine kinase 1

Symbol:

NTRK1

Pathway:

Apoptosis, Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Thyroid cancer

Function:

Druggable Genome, Protein Kinase, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com