Product overview:

TNFRSF18 mouse monoclonal antibody, clone LBI1A3

Field of research:

Cytokine-cytokine receptor interaction

Summary:

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb

Alternative names:

AITR; CD357; GITR; GITR-D

Species reactivity:

Human

Host:

Mouse

Target:

TNFRSF18

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 26-162 of human TNFRSF18(NP_004186) produced in E.coli.

Clone:

LBI1A3

Conjugation:

Unconjugated

Gene name:

tumor necrosis factor receptor superfamily member 18

Symbol:

TNFRSF18

Pathway:

Cytokine-cytokine receptor interaction

Function:

Druggable Genome, Secreted Protein, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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