Product overview:

CLDN3 mouse monoclonal antibody, clone LBI1E7

Field of research:

Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

Summary:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

Alternative names:

C7orf1; CPE-R2; CPETR2; HRVP1; RVP1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

CLDN3

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human CLDN3 (NP_001297) produced in HEK293T cell.

Clone:

LBI1E7

Conjugation:

Unconjugated

Gene name:

claudin 3

Symbol:

CLDN3

Pathway:

Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com