Product overview:

TFPI mouse monoclonal antibody, clone LBI3C2

Field of research:

Complement and coagulation cascades

Summary:

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]

Alternative names:

EPI; LACI; TFI; TFPI1

Species reactivity:

Human

Host:

Mouse

Target:

TFPI

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 29-304 of human TFPI (NP_006278) produced in E.coli.

Clone:

LBI3C2

Conjugation:

Unconjugated

Gene name:

tissue factor pathway inhibitor

Symbol:

TFPI

Pathway:

Complement and coagulation cascades

Function:

Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

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