Product overview:

ADAMTS4 mouse monoclonal antibody, clone LBI2G8

Field of research:

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Summary:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]

Alternative names:

ADAMTS-2; ADAMTS-4; ADMP-1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

ADAMTS4

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 296-577 of human ADAMTS4 (NP_005090) produced in E.coli.

Clone:

LBI2G8

Conjugation:

Unconjugated

Gene name:

ADAM metallopeptidase with thrombospondin type 1 motif 4

Symbol:

ADAMTS4

Pathway:

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Function:

Druggable Genome, Protease, Secreted Protein, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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