Product overview:

APOE mouse monoclonal antibody, clone LBI2A4

Field of research:

Alzheimer's disease

Summary:

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008]

Alternative names:

AD2; APO-E; LDLCQ5; LPG

Species reactivity:

Human

Host:

Mouse

Target:

APOE

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human APOE (NP_000032) produced in HEK293T cell.

Clone:

LBI2A4

Conjugation:

Unconjugated

Gene name:

apolipoprotein E

Symbol:

APOE

Pathway:

Alzheimer's disease

Function:

Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com