Product overview:

PLAU mouse monoclonal antibody, clone LBI6H4

Field of research:

Complement and coagulation cascades

Summary:

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Alternative names:

ATF; BDPLT5; QPD; u-PA; UPA; URK

Species reactivity:

Human

Host:

Mouse

Target:

PLAU

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 107-379 of human PLAU (NP_002649) produced in E.coli.

Clone:

LBI6H4

Conjugation:

Unconjugated

Gene name:

plasminogen activator, urokinase

Symbol:

PLAU

Pathway:

Complement and coagulation cascades

Function:

Druggable Genome, ES Cell Differentiation/IPS, Protease

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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