Product overview:

CCL2 mouse monoclonal antibody, clone LBI1G4

Field of research:

Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

Summary:

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul

Alternative names:

GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF

Species reactivity:

Human

Host:

Mouse

Target:

CCL2

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 24-99 of human CCL2 (NP_002973) produced in E.coli.

Clone:

LBI1G4

Conjugation:

Unconjugated

Gene name:

C-C motif chemokine ligand 2

Symbol:

CCL2

Pathway:

Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

Function:

Druggable Genome, Secreted Protein

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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