Product overview:

CDH4 mouse monoclonal antibody, clone LBI4D9

Field of research:

Cell adhesion molecules (CAMs)

Summary:

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Alternative names:

CAD4; R-CAD; RCAD

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

CDH4

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 170-428 of human CDH4 (NP_001785) produced in E.coli.

Clone:

LBI4D9

Conjugation:

Unconjugated

Gene name:

cadherin 4

Symbol:

CDH4

Pathway:

Cell adhesion molecules (CAMs)

Function:

Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

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