Product overview:

XRCC3 mouse monoclonal antibody, clone LBI4F3

Field of research:

Homologous recombination

Summary:

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Alternative names:

CMM6

Species reactivity:

Human

Host:

Mouse

Target:

XRCC3

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1-235 of human XRCC3 (NP_005423) produced in E.coli.

Clone:

LBI4F3

Conjugation:

Unconjugated

Gene name:

X-ray repair complementing defective repair in Chinese hamster cells 3

Symbol:

XRCC3

Pathway:

Homologous recombination

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

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