Product overview:

ERBB4 mouse monoclonal antibody,clone LBI1H6

Field of research:

Calcium signaling pathway, Endocytosis, ErbB signaling pathway

Summary:

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Alternative names:

ALS19; HER4; p180erbB4

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

ERBB4

Isotype:

IgG2b

Immunogen:

Human recombinant protein fragment corresponding to amino acids 992-1308 of human ERBB4 (NP_005226) produced in E.coli.

Clone:

LBI1H6

Conjugation:

Unconjugated

Gene name:

erb-b2 receptor tyrosine kinase 4

Symbol:

ERBB4

Pathway:

Calcium signaling pathway, Endocytosis, ErbB signaling pathway

Function:

Druggable Genome, Protein Kinase, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

IHC 1:1000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com