Product overview:

DCC mouse monoclonal antibody, clone LBI4A1

Field of research:

Axon guidance, Colorectal cancer, Pathways in cancer

Summary:

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

Alternative names:

CRC18; CRCR1; IGDCC1; MRMV1; NTN1R1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

DCC

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human DCC (NP_005206) produced in HEK293T cell.

Clone:

LBI4A1

Conjugation:

Unconjugated

Gene name:

DCC netrin 1 receptor

Symbol:

DCC

Pathway:

Axon guidance, Colorectal cancer, Pathways in cancer

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:200

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com