Product overview:

RRM1 mouse monoclonal antibody, clone LBI12B9

Field of research:

Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

Summary:

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]

Alternative names:

R1; RIR1; RR1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

RRM1

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 541-792 of human RRM1 (NP_001024) produced in E.coli.

Clone:

LBI12B9

Conjugation:

Unconjugated

Gene name:

ribonucleotide reductase catalytic subunit M1

Symbol:

RRM1

Pathway:

Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com