Product overview:

Purified IKZF3 mouse monoclonal antibody, clone LBI5E2

Field of research:

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Summary:

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

Alternative names:

AIO; AIOLOS; ZNFN1A3

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

IKZF3

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1-301 of human IKZF3 (NP_036613) produced in E.coli.

Clone:

LBI5E2

Conjugation:

Unconjugated

Gene name:

IKAROS family zinc finger 3

Symbol:

IKZF3

Pathway:

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Function:

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Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

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