Product overview:

Purified MAPKAPK5 mouse monoclonal antibody, clone LBI5E1

Field of research:

MAPK signaling pathway

Summary:

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov

Alternative names:

MAPKAP-K5; MK-5; MK5; PRAK

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

MAPKAPK5

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 197-471 of human MAPKAPK5 (NP_003659) produced in E.coli.

Clone:

LBI5E1

Conjugation:

Unconjugated

Gene name:

mitogen-activated protein kinase-activated protein kinase 5

Symbol:

MAPKAPK5

Pathway:

MAPK signaling pathway

Function:

Druggable Genome, Protein Kinase

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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