Product overview:

GLI1 mouse monoclonal antibody, clone LBI2D5E12

Field of research:

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Summary:

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Alternative names:

GLI

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

GLI1

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 755-1106 of human GLI1 (NP_005260) produced in E.coli.

Clone:

LBI2D5E12

Conjugation:

Unconjugated

Gene name:

GLI family zinc finger 1

Symbol:

GLI1

Pathway:

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Function:

Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com