Product overview:

IFIH1 (MDA5) mouse monoclonal antibody, clone LBI11C11

Field of research:

RIG-I-like receptor signaling pathway

Summary:

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]

Alternative names:

AGS7; Hlcd; IDDM19; MDA-5; MDA5; RLR-2; SGMRT1

Species reactivity:

Human

Host:

Mouse

Target:

IFIH1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human IFIH1 (NP_071451) produced in HEK293T cell.

Clone:

LBI11C11

Conjugation:

Unconjugated

Gene name:

interferon induced with helicase C domain 1

Symbol:

IFIH1

Pathway:

RIG-I-like receptor signaling pathway

Function:

Request info at info@sobekbio.com

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com