Product overview:

SMPD1 mouse monoclonal antibody, clone LBI3H7

Field of research:

Lysosome, Metabolic pathways, Sphingolipid metabolism

Summary:

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]

Alternative names:

ASM; ASMASE; NPD

Species reactivity:

Human

Host:

Mouse

Target:

SMPD1

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 62-341 of human SMPD1 (NP_000534) produced in E.coli.

Clone:

LBI3H7

Conjugation:

Unconjugated

Gene name:

sphingomyelin phosphodiesterase 1

Symbol:

SMPD1

Pathway:

Lysosome, Metabolic pathways, Sphingolipid metabolism

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com