Product overview:

DDOST mouse monoclonal antibody, clone LBI2H2

Field of research:

Metabolic pathways, N-Glycan biosynthesis

Summary:

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]

Alternative names:

AGER1; CDG1R; OKSWcl45; OST; OST48; WBP1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

DDOST

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 131-378 of human DDOST (NP_005207) produced in E.coli.

Clone:

LBI2H2

Conjugation:

Unconjugated

Gene name:

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

Symbol:

DDOST

Pathway:

Metabolic pathways, N-Glycan biosynthesis

Function:

Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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