Product overview:

Purified GBA mouse monoclonal antibody, clone LBI1C7

Field of research:

Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism

Summary:

This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Alternative names:

GBA1; GCB; GLUC

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

GBA

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 40-315 of human GBA (NP_000148) produced in E.coli.

Clone:

LBI1C7

Conjugation:

Unconjugated

Gene name:

glucosylceramidase beta

Symbol:

GBA

Pathway:

Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com