Product overview:

PDE1A mouse monoclonal antibody, clone LBI5C9

Field of research:

Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism, Taste transduction

Summary:

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]). [supplied by OMIM, Oct 2009]

Alternative names:

CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PDE1A

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 259-545 of human PDE1A (NP_005010) produced in E.coli.

Clone:

LBI5C9

Conjugation:

Unconjugated

Gene name:

phosphodiesterase 1A

Symbol:

PDE1A

Pathway:

Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism, Taste transduction

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com