Product overview:

DOCK2 mouse monoclonal antibody, clone LBI7G2

Field of research:

Chemokine signaling pathway, Fc gamma R-mediated phagocytosis

Summary:

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]

Alternative names:

IMD40

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

DOCK2

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1544-1830 of human DOCK2 (NP_004937) produced in E.coli.

Clone:

LBI7G2

Conjugation:

Unconjugated

Gene name:

dedicator of cytokinesis 2

Symbol:

DOCK2

Pathway:

Chemokine signaling pathway, Fc gamma R-mediated phagocytosis

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com