Product overview:

KDR mouse monoclonal antibody, clone LBI12C1

Field of research:

Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, VEGF signaling pathway

Summary:

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

Alternative names:

CD309; FLK1; VEGFR; VEGFR2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

KDR

Isotype:

IgG2a

Immunogen:

Human recombinant protein fragment corresponding to amino acids 786-1356 of human KDR (NP_002244) produced in HEK293T cell.

Clone:

LBI12C1

Conjugation:

Unconjugated

Gene name:

kinase insert domain receptor

Symbol:

KDR

Pathway:

Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, VEGF signaling pathway

Function:

Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com