Product overview:

DDIT3 mouse monoclonal antibody,clone LBI1E7

Field of research:

MAPK signaling pathway

Summary:

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

Alternative names:

CEBPZ; CHOP; CHOP-10; CHOP10; GADD153

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

DDIT3

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human DDIT3 (NP_004074) produced in E.coli.

Clone:

LBI1E7

Conjugation:

Unconjugated

Gene name:

DNA damage inducible transcript 3

Symbol:

DDIT3

Pathway:

MAPK signaling pathway

Function:

Druggable Genome, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

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