Product overview:

TNFRSF8 mouse monoclonal antibody, clone LBI3B10

Field of research:

Cytokine-cytokine receptor interaction

Summary:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Alternative names:

CD30; D1S166E; Ki-1

Species reactivity:

Human

Host:

Mouse

Target:

TNFRSF8

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 19-379 of human TNFRSF8 (NP_001234) produced in E.coli.

Clone:

LBI3B10

Conjugation:

Unconjugated

Gene name:

tumor necrosis factor receptor superfamily member 8

Symbol:

TNFRSF8

Pathway:

Cytokine-cytokine receptor interaction

Function:

Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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