Product overview:

PIK3C2A mouse monoclonal antibody, clone LBI2G10

Field of research:

Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Summary:

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

Alternative names:

CPK; PI3-K-C2(ALPHA); PI3-K-C2A

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PIK3C2A

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 230-560 of human PIK3C2A (NP_002636) produced in E.coli.

Clone:

LBI2G10

Conjugation:

Unconjugated

Gene name:

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Symbol:

PIK3C2A

Pathway:

Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com