Product overview:

RASGRP3 mouse monoclonal antibody, clone LBI5D2

Field of research:

B cell receptor signaling pathway, MAPK signaling pathway

Summary:

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]). [supplied by OMIM, Mar 2008]

Alternative names:

GRP3

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

RASGRP3

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 380-690 of human RASGRP3 (NP_733772) produced in E.coli.

Clone:

LBI5D2

Conjugation:

Unconjugated

Gene name:

RAS guanyl releasing protein 3

Symbol:

RASGRP3

Pathway:

B cell receptor signaling pathway, MAPK signaling pathway

Function:

Request info at info@sobekbio.com

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com