Product overview:

NBN mouse monoclonal antibody, clone LBI7D5

Field of research:

Homologous recombination

Summary:

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]

Alternative names:

AT-V1; AT-V2; ATV; NBS; NBS1; P95

Species reactivity:

Human

Host:

Mouse

Target:

NBN

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 183-460 of human NBN (NP_002476) produced in E.coli.

Clone:

LBI7D5

Conjugation:

Unconjugated

Gene name:

nibrin

Symbol:

NBN

Pathway:

Homologous recombination

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

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