Product overview:

TYR mouse monoclonal antibody, clone LBI1F3

Field of research:

Melanogenesis, Metabolic pathways, Riboflavin metabolism, Tyrosine metabolism

Summary:

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]

Alternative names:

ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

TYR

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 19-320 of human TYR (NP_000363) produced in E.coli.

Clone:

LBI1F3

Conjugation:

Unconjugated

Gene name:

tyrosinase

Symbol:

TYR

Pathway:

Melanogenesis, Metabolic pathways, Riboflavin metabolism, Tyrosine metabolism

Function:

Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com