Product overview:

NEFL mouse monoclonal antibody, clone LBI11F6

Field of research:

Amyotrophic lateral sclerosis (ALS)

Summary:

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]

Alternative names:

CMT1F; CMT2E; NF-L; NF68; NFL; PPP1R110

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

NEFL

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1-360 of human NEFL (NP_006149) produced in E.coli.

Clone:

LBI11F6

Conjugation:

Unconjugated

Gene name:

neurofilament, light polypeptide

Symbol:

NEFL

Pathway:

Amyotrophic lateral sclerosis (ALS)

Function:

Druggable Genome, ES Cell Differentiation/IPS

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:500

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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