Product overview:

CDKN2C (p18 INK4c) mouse monoclonal antibody, clone LBI1E4

Field of research:

Cell cycle

Summary:

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Alternative names:

INK4C; p18; p18-INK4C

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

CDKN2C

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human CDKN2C (NP_001253) produced in E.coli.

Clone:

LBI1E4

Conjugation:

Unconjugated

Gene name:

cyclin-dependent kinase inhibitor 2C

Symbol:

CDKN2C

Pathway:

Cell cycle

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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