Product overview:

HSD17B8 mouse monoclonal antibody, clone LBI6H2

Field of research:

Androgen and estrogen metabolism, Metabolic pathways

Summary:

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

Alternative names:

D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6; HKE6; KE6; RING2; SDR30C1

Species reactivity:

Human, Mouse, Rat, Dog

Host:

Mouse

Target:

HSD17B8

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 57-261 of human HSD17B8 (NP_055049) produced in E.coli.

Clone:

LBI6H2

Conjugation:

Unconjugated

Gene name:

hydroxysteroid (17-beta) dehydrogenase 8

Symbol:

HSD17B8

Pathway:

Androgen and estrogen metabolism, Metabolic pathways

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com