Product overview:

METAP2 (Methionine Aminopeptidase 2) mouse monoclonal antibody, clone LBI1F6

Field of research:

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Summary:

This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq]

Alternative names:

MAP2; MNPEP; p67eIF2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

METAP2

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 2-212 of human METAP2 (NP_006829) produced in E.coli.

Clone:

LBI1F6

Conjugation:

Unconjugated

Gene name:

methionyl aminopeptidase 2

Symbol:

METAP2

Pathway:

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Function:

Druggable Genome, Protease

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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