Product overview:

CD74 mouse monoclonal antibody, clone LBI1G10

Field of research:

Antigen processing and presentation

Summary:

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Alternative names:

DHLAG; HLADG; Ia-GAMMA; II

Species reactivity:

Human

Host:

Mouse

Target:

CD74

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human CD74(NP_001020330) produced in HEK293T cell.

Clone:

LBI1G10

Conjugation:

Unconjugated

Gene name:

CD74 molecule

Symbol:

CD74

Pathway:

Antigen processing and presentation

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:4000, IHC 1:150

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com