Product overview:

UNC13D mouse monoclonal antibody, clone LBI1F4

Field of research:

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Summary:

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]

Alternative names:

FHL3; HLH3; HPLH3; Munc13-4

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

UNC13D

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human UNC13D(NP_954712) produced in HEK293T cell.

Clone:

LBI1F4

Conjugation:

Unconjugated

Gene name:

unc-13 homolog D

Symbol:

UNC13D

Pathway:

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Function:

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Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:200~1000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

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