Product overview:

CLDN6 mouse monoclonal antibody, clone LBI3E3

Field of research:

Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

Summary:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16. [provided by RefSeq, Aug 2010]

Alternative names:

claudin 6; OTTHUMP00000159248

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

CLDN6

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human CLDN6(NP_067018) produced in HEK293T cell.

Clone:

LBI3E3

Conjugation:

Unconjugated

Gene name:

claudin 6

Symbol:

CLDN6

Pathway:

Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

Function:

Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:1000, IF 1:100

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com