Product overview:

Purified IL10RA mouse monoclonal antibody, clone LBI1C7

Field of research:

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Summary:

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

Alternative names:

CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R

Species reactivity:

Human

Host:

Mouse

Target:

IL10RA

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human IL10RA(NP_001549) produced in HEK293T cell.

Clone:

LBI1C7

Conjugation:

Unconjugated

Gene name:

interleukin 10 receptor subunit alpha

Symbol:

IL10RA

Pathway:

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

1 mg/ml

Form:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Applications & dilution:

WB 1:4000

Storage buffer:

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage:

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com